An Update on Transdermal Melatonin Use, Sleep Challenges and Jet Lag

Ask a frequent flyer about melatonin and you will probably be met with mixed reviews. While the melatonin website offers a long list of contra-indications (1) users still find it useful to a point. It now looks like the less is more dictum of using melatonin will replace the excessive use of the past. Research is now suggesting that low dose melatonin delivered via the skin (2) may better serve those with sleep challenges including jet lagged frequent flyers.

The jet lag problem faced by frequent flyers hgm was never going to be cured by melatonin alone. Flyers looking for a consummate solution should look at all aspects of their frequent flying lifestyle, however a review of the current research suggests melatonin can play a healthy role in the arsenal of tools at the disposal of frequent flyers.

Here is a round-up of what we know about melatonin at the moment. Starting with melatonin suppression (3), a lack encourages

 

  • Cancer proliferation
  • Immunity compromise
  • Disordered energy metabolism
  • Compromised reproductive function and
  • Altered eating behaviors

 

Normal melatonin production encourages

 

  • Super antioxidant protection throughout the body
  • Immunological modulation
  • Sleep onset and
  • Regulates hormonal function

 

The buzz surrounding melatonin shifted gears with research suggesting transdermal melatonin application may be of benefit where traditional melatonin use previously failed. Failures of note are oral melatonin’s short elimination half-life cycle, which meant while sleep onset could be achieved, maintaining sleep for the duration was not guaranteed. Another challenge was the possibility of overloading the liver with oral melatonin and its metabolites. As disruptive as this is a knock on effect is in how these metabolites interact with other aspects of the endocrine system.

 

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